Inferring functional transcription factor-gene binding pairs by integrating transcription factor binding data with transcription factor knockout data
نویسندگان
چکیده
منابع مشابه
Integrating genomic data to predict transcription factor binding.
Transcription factor binding sites (TFBS) in gene promoter regions are often predicted by using position specific scoring matrices (PSSMs), which summarize sequence patterns of experimentally determined TF binding sites. Although PSSMs are more reliable than simple consensus string matching in predicting a true binding site, they generally result in high numbers of false positive hits. This stu...
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Multi-sample microarray experiments have become a standard experimental method for studying biological systems. A frequent goal in such studies is to unravel the regulatory relationships between genes. During the last few years, regression models have been proposed for the de novo discovery of cis-acting regulatory sequences using gene expression data. However, when applied to multi-sample expe...
متن کاملIntegrating transcription factor binding site information with gene expression datasets
MOTIVATION Microarrays are widely used to measure gene expression differences between sets of biological samples. Many of these differences will be due to differences in the activities of transcription factors. In principle, these differences can be detected by associating motifs in promoters with differences in gene expression levels between the groups. In practice, this is hard to do. RESUL...
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κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
متن کاملMapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels
κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2013
ISSN: 1752-0509
DOI: 10.1186/1752-0509-7-s6-s13